When Xiwen finally gets engaged, her best friends decide to celebrate with a last wild bachelorette trip, and choose Vietnam because one of the bridesmaids Xiaomei is filming a movie there. Besides Xiwen's longtime best friend Kimmy, the gang includes her fiance's little sister Jingjing and er other best friend the glamorous Jialan, who was Kimmy's bitter rival in school. Jialan deliberately comes back from Paris for the trip and immediately opens warfare with Kimmy, with Xiwengamely trying to keep the peace.
After the girls arrive in Ho Chi Minh City, Xiaomei asks them to meet her at private villa party hosted by her handsome film investor, the richest man in Vietnam. Kimmy and Jialan try to outdo each other to get his attention, and end by chugging powerful, disgusting local spirits infused with scorpions, lizards and snakes....
The next day, the girls wake up on the beach, hungover, naked and handcuffed to a locked briefcase, with a strange tattoo on Xiwen's neck, and Jingjing nowhere to be seen. Soon they find themselves chased by local gangsters on motorbikes led by the buxom and deadly Elly. With the help of a kind ex-boxing champ, the girls race to piece together what happened the night before in order to save Jingjing and Xiwen's engagement.